Public report
Patent-Cliff Watchlist
U.S. small-molecule drugs flagged for near-term Orange Book patent expiry signals, ranked by expiry attractiveness and confidence.
This is a screening tool, not legal advice. Patent and exclusivity interpretation requires qualified legal review before commercial decisions are made. Data sourced from FDA Orange Book as of June 6, 2026.
Opportunity MatrixNear-term LOE × low patent complexity — bottom-left quadrant is most actionable
Hover any drug to see details — bottom-left is simplest portfolio entry window
CNS
Dermatology
Gastroenterology
Pain
Respiratory
Patent complexity and Clinical competition are scored 0–5 (more dots = higher). Lower complexity and lower competition generally indicate a cleaner generic entry window. Click column headers to sort.
| Active ingredient | Applicant | Patent expiry | Confidence | |||||
|---|---|---|---|---|---|---|---|---|
| VERDESO | Dermatology | DESONIDE | GENUS | 14mo | August 13, 2027 | Medium | ||
| ALVESCO | Respiratory | CICLESONIDE | COVIS | 20mo | February 1, 2028 | Medium | ||
| ZETONNA | Respiratory | CICLESONIDE | AZURITY | 20mo | February 1, 2028 | Medium | ||
| SORILUX | Dermatology | CALCIPOTRIENE | MAYNE PHARMA | 23mo | May 7, 2028 | Medium | ||
| OLUX E | Dermatology | CLOBETASOL PROPIONATE | PHARMOBEDIENT | 29mo | November 5, 2028 | Medium | ||
| FINACEA | Dermatology | AZELAIC ACID | LEO PHARMA AS | 33mo | February 28, 2029 | Medium | ||
| MYDAYIS | CNS | AMPHETAMINE ASPARTATE; AMPHETAMINE SULFATE; DEXTROAMPHETAMINE SACCHARATE; DEXTROAMPHETAMINE SULFATE | TAKEDA PHARMS USA | 39mo | August 24, 2029 | Medium | ||
| EMBEDA | Pain | MORPHINE SULFATE; NALTREXONE HYDROCHLORIDE | ALPHARMA PHARMS | 41mo | November 7, 2029 | Medium | ||
| ATROVENT HFA | Respiratory | IPRATROPIUM BROMIDE | BOEHRINGER INGELHEIM | 43mo | January 17, 2030 | Medium | ||
| FABIOR | Dermatology | TAZAROTENE | MAYNE PHARMA | 45mo | February 24, 2030 | Medium | ||
| APRISO | Gastroenterology | MESALAMINE | SALIX | 47mo | May 1, 2030 | Medium | ||
| AIRSUPRA | Respiratory | ALBUTEROL SULFATE; BUDESONIDE | ASTRAZENECA | 48mo | May 28, 2030 | Medium | ||
| SYMBICORT AEROSPHERE | Respiratory | BUDESONIDE; FORMOTEROL FUMARATE | ASTRAZENECA | 48mo | May 28, 2030 | Medium |