Manual Review Required

PD-L1 expression

solid tumor basket · Monoclonal Antibody

PD-L1 expression is flagged as manual review required because public trials show inclusion required evidence in 56 contexts. FDA CDx context should be reviewed manually.

Role evidence

Usage summary

Strongest role: Inclusion Required

Inclusion-required count: 31

Treatment-assignment count: 0

Stratification count: 1

Threshold snippets

Fragmentation view

Threshold count: 27

Common snippets: dMMR | MSI-H | dMMR

Threshold label: Moderate

FDA CDx context

Mapping summary

CDx label: Fda Cdx Context Manual Review Required

CDx maturity score: 2/5

Confidence: Low

Patent-density signal

Diagnostic appendix

Signal count: 1

Recent signals: 1

Density label: Low

Source links

Evidence paths

https://clinicaltrials.gov/study/NCT02420821 | https://clinicaltrials.gov/study/NCT05942378 | https://clinicaltrials.gov/study/NCT03753659 | https://clinicaltrials.gov/study/NCT01358721 | https://clinicaltrials.gov/study/NCT04878029 | https://clinicaltrials.gov/study/NCT03141684 | https://clinicaltrials.gov/study/NCT02410512 | https://clinicaltrials.gov/study/NCT02671955 | https://clinicaltrials.gov/study/NCT05631899 | https://clinicaltrials.gov/study/NCT05979740 | https://clinicaltrials.gov/study/NCT06989112 | https://clinicaltrials.gov/study/NCT04162327 | https://clinicaltrials.gov/study/NCT01714739 | https://clinicaltrials.gov/study/NCT02560636 | https://clinicaltrials.gov/study/NCT03700476 | https://clinicaltrials.gov/study/NCT03024996 | https://clinicaltrials.gov/study/NCT02938793 | https://clinicaltrials.gov/study/NCT05128539 | https://clinicaltrials.gov/study/NCT02837029 | https://clinicaltrials.gov/study/NCT04653389 | https://clinicaltrials.gov/study/NCT06511726 | https://clinicaltrials.gov/study/NCT04214249 | https://clinicaltrials.gov/study/NCT04165317 | https://clinicaltrials.gov/study/NCT02399371 | https://clinicaltrials.gov/study/NCT03984357 | https://clinicaltrials.gov/study/NCT04413838 | https://clinicaltrials.gov/study/NCT03014804 | https://clinicaltrials.gov/study/NCT03657381 | https://clinicaltrials.gov/study/NCT07205731 | https://clinicaltrials.gov/study/NCT03795207 | https://clinicaltrials.gov/study/NCT07465276 | https://clinicaltrials.gov/study/NCT06035224 | https://clinicaltrials.gov/study/NCT03736889 | https://clinicaltrials.gov/study/NCT07053332 | https://clinicaltrials.gov/study/NCT03810339 | https://clinicaltrials.gov/study/NCT04068519 | https://clinicaltrials.gov/study/NCT03704246 | https://clinicaltrials.gov/study/NCT02715284 | https://clinicaltrials.gov/study/NCT06046274 | https://clinicaltrials.gov/study/NCT04547101 | https://clinicaltrials.gov/study/NCT03474640 | https://clinicaltrials.gov/study/NCT04486352 | https://clinicaltrials.gov/study/NCT05890742 | https://clinicaltrials.gov/study/NCT06321068 | https://clinicaltrials.gov/study/NCT06400264 | https://clinicaltrials.gov/study/NCT05152212 | https://clinicaltrials.gov/study/NCT04551521 | https://clinicaltrials.gov/study/NCT03816553 | https://clinicaltrials.gov/study/NCT05520619 | https://clinicaltrials.gov/study/NCT04080804 | https://clinicaltrials.gov/study/NCT04669496 | https://clinicaltrials.gov/study/NCT07646301 | https://clinicaltrials.gov/study/NCT05994001 | https://clinicaltrials.gov/study/NCT04856150 | https://clinicaltrials.gov/study/NCT06166472 | https://clinicaltrials.gov/study/NCT05980416