Role evidence
Usage summary
Strongest role: Inclusion Required
Inclusion-required count: 16
Treatment-assignment count: 0
Stratification count: 1
Manual Review Required
MSI-H / dMMR
solid tumor basket · Therapy Not Normalized
MSI-H / dMMR is flagged as manual review required because public trials show inclusion required evidence in 39 contexts. FDA CDx context should be reviewed manually.
Threshold snippets
Fragmentation view
Threshold count: 61
Common snippets: MSI-H | BRAF V600E | MSI-H
Threshold label: Moderate
FDA CDx context
Mapping summary
CDx label: Fda Cdx Context Manual Review Required
CDx maturity score: 2/5
Confidence: Low
Patent-density signal
Diagnostic appendix
Signal count: 0
Recent signals: 0
Density label: Low
Source links
Evidence paths
https://clinicaltrials.gov/study/NCT07259889 | https://clinicaltrials.gov/study/NCT03762447 | https://clinicaltrials.gov/study/NCT07617818 | https://clinicaltrials.gov/study/NCT04906382 | https://clinicaltrials.gov/study/NCT07208136 | https://clinicaltrials.gov/study/NCT05723562 | https://clinicaltrials.gov/study/NCT06475599 | https://clinicaltrials.gov/study/NCT07374809 | https://clinicaltrials.gov/study/NCT07431073 | https://clinicaltrials.gov/study/NCT07552376 | https://clinicaltrials.gov/study/NCT04242199 | https://clinicaltrials.gov/study/NCT07140679 | https://clinicaltrials.gov/study/NCT04165772 | https://clinicaltrials.gov/study/NCT07240857 | https://clinicaltrials.gov/study/NCT03059823 | https://clinicaltrials.gov/study/NCT06762405 | https://clinicaltrials.gov/study/NCT06640049 | https://clinicaltrials.gov/study/NCT06898450 | https://clinicaltrials.gov/study/NCT06897527 | https://clinicaltrials.gov/study/NCT03941574 | https://clinicaltrials.gov/study/NCT04443543 | https://clinicaltrials.gov/study/NCT04291248 | https://clinicaltrials.gov/study/NCT07593144 | https://clinicaltrials.gov/study/NCT05855200 | https://clinicaltrials.gov/study/NCT06686576 | https://clinicaltrials.gov/study/NCT07413146 | https://clinicaltrials.gov/study/NCT03833661 | https://clinicaltrials.gov/study/NCT04450901 | https://clinicaltrials.gov/study/NCT06278857 | https://clinicaltrials.gov/study/NCT07163403 | https://clinicaltrials.gov/study/NCT05301764 | https://clinicaltrials.gov/study/NCT06215677 | https://clinicaltrials.gov/study/NCT04393454 | https://clinicaltrials.gov/study/NCT02497820 | https://clinicaltrials.gov/study/NCT05255653 | https://clinicaltrials.gov/study/NCT05961709 | https://clinicaltrials.gov/study/NCT03053466 | https://clinicaltrials.gov/study/NCT05001516 | https://clinicaltrials.gov/study/NCT05707676