Manual Review Required

MET exon 14 skipping

solid tumor basket · Small Molecule Inhibitor

MET exon 14 skipping is flagged as manual review required because public trials show inclusion required evidence in 146 contexts. FDA CDx context should be reviewed manually. Threshold text varies across public records.

Role evidence

Usage summary

Strongest role: Inclusion Required

Inclusion-required count: 117

Treatment-assignment count: 1

Stratification count: 0

Threshold snippets

Fragmentation view

Threshold count: 65

Common snippets: PD-L1 CPS ≥1 | BRAF V600E | BRAF V600E

Threshold label: Fragmented

FDA CDx context

Mapping summary

CDx label: Fda Cdx Context Not Found

CDx maturity score: 1/5

Confidence: Low

Patent-density signal

Diagnostic appendix

Signal count: 0

Recent signals: 0

Density label: Low

Source links

Evidence paths

https://clinicaltrials.gov/study/NCT02045095 | https://clinicaltrials.gov/study/NCT02389309 | https://clinicaltrials.gov/study/NCT01286467 | https://clinicaltrials.gov/study/NCT06126276 | https://clinicaltrials.gov/study/NCT01353625 | https://clinicaltrials.gov/study/NCT03237390 | https://clinicaltrials.gov/study/NCT02467361 | https://clinicaltrials.gov/study/NCT00504205 | https://clinicaltrials.gov/study/NCT04072042 | https://clinicaltrials.gov/study/NCT01859351 | https://clinicaltrials.gov/study/NCT03370302 | https://clinicaltrials.gov/study/NCT06223542 | https://clinicaltrials.gov/study/NCT07071103 | https://clinicaltrials.gov/study/NCT05538897 | https://clinicaltrials.gov/study/NCT01762410 | https://clinicaltrials.gov/study/NCT03803774 | https://clinicaltrials.gov/study/NCT01294202 | https://clinicaltrials.gov/study/NCT02630251 | https://clinicaltrials.gov/study/NCT06914128 | https://clinicaltrials.gov/study/NCT01899053 | https://clinicaltrials.gov/study/NCT03188965 | https://clinicaltrials.gov/study/NCT01332279 | https://clinicaltrials.gov/study/NCT01668550 | https://clinicaltrials.gov/study/NCT05396833 | https://clinicaltrials.gov/study/NCT00927823 | https://clinicaltrials.gov/study/NCT02049593 | https://clinicaltrials.gov/study/NCT03065387 | https://clinicaltrials.gov/study/NCT02219711 | https://clinicaltrials.gov/study/NCT00028587 | https://clinicaltrials.gov/study/NCT01425879 | https://clinicaltrials.gov/study/NCT01441388 | https://clinicaltrials.gov/study/NCT01589302 | https://clinicaltrials.gov/study/NCT02944617 | https://clinicaltrials.gov/study/NCT07662720 | https://clinicaltrials.gov/study/NCT02223923 | https://clinicaltrials.gov/study/NCT02327169 | https://clinicaltrials.gov/study/NCT00422682 | https://clinicaltrials.gov/study/NCT03345784 | https://clinicaltrials.gov/study/NCT06433726 | https://clinicaltrials.gov/study/NCT02540876 | https://clinicaltrials.gov/study/NCT04601857 | https://clinicaltrials.gov/study/NCT03786237 | https://clinicaltrials.gov/study/NCT04729725 | https://clinicaltrials.gov/study/NCT07404332 | https://clinicaltrials.gov/study/NCT04954001 | https://clinicaltrials.gov/study/NCT03175497 | https://clinicaltrials.gov/study/NCT07695142 | https://clinicaltrials.gov/study/NCT01582191 | https://clinicaltrials.gov/study/NCT05172245 | https://clinicaltrials.gov/study/NCT01991938 | https://clinicaltrials.gov/study/NCT01999972 | https://clinicaltrials.gov/study/NCT01213381 | https://clinicaltrials.gov/study/NCT02746081 | https://clinicaltrials.gov/study/NCT01004861 | https://clinicaltrials.gov/study/NCT01217450 | https://clinicaltrials.gov/study/NCT01692496 | https://clinicaltrials.gov/study/NCT02432417 | https://clinicaltrials.gov/study/NCT05710406 | https://clinicaltrials.gov/study/NCT05370469 | https://clinicaltrials.gov/study/NCT04591002 | https://clinicaltrials.gov/study/NCT01573702 | https://clinicaltrials.gov/study/NCT05578092 | https://clinicaltrials.gov/study/NCT06322095 | https://clinicaltrials.gov/study/NCT01449201 | https://clinicaltrials.gov/study/NCT04222335 | https://clinicaltrials.gov/study/NCT05507541 | https://clinicaltrials.gov/study/NCT06692491 | https://clinicaltrials.gov/study/NCT03239015 | https://clinicaltrials.gov/study/NCT03719898 | https://clinicaltrials.gov/study/NCT05638295 | https://clinicaltrials.gov/study/NCT05367778 | https://clinicaltrials.gov/study/NCT03785249 | https://clinicaltrials.gov/study/NCT06959615 | https://clinicaltrials.gov/study/NCT06973564 | https://clinicaltrials.gov/study/NCT06739395 | https://clinicaltrials.gov/study/NCT04975256 | https://clinicaltrials.gov/study/NCT03994796 | https://clinicaltrials.gov/study/NCT04185883 | https://clinicaltrials.gov/study/NCT06659341 | https://clinicaltrials.gov/study/NCT04330664 | https://clinicaltrials.gov/study/NCT07172919 | https://clinicaltrials.gov/study/NCT06804824 | https://clinicaltrials.gov/study/NCT05178888 | https://clinicaltrials.gov/study/NCT06340568 | https://clinicaltrials.gov/study/NCT07142200 | https://clinicaltrials.gov/study/NCT02268747 | https://clinicaltrials.gov/study/NCT00551850 | https://clinicaltrials.gov/study/NCT05821751 | https://clinicaltrials.gov/study/NCT05445648 | https://clinicaltrials.gov/study/NCT02935361 | https://clinicaltrials.gov/study/NCT03082534 | https://clinicaltrials.gov/study/NCT03495323 | https://clinicaltrials.gov/study/NCT04284787 | https://clinicaltrials.gov/study/NCT07238569 | https://clinicaltrials.gov/study/NCT06418724 | https://clinicaltrials.gov/study/NCT04550624 | https://clinicaltrials.gov/study/NCT03884998 | https://clinicaltrials.gov/study/NCT03971214 | https://clinicaltrials.gov/study/NCT04963153 | https://clinicaltrials.gov/study/NCT04800978 | https://clinicaltrials.gov/study/NCT05659251 | https://clinicaltrials.gov/study/NCT05425602 | https://clinicaltrials.gov/study/NCT07497919 | https://clinicaltrials.gov/study/NCT05354323 | https://clinicaltrials.gov/study/NCT06614140 | https://clinicaltrials.gov/study/NCT04282109 | https://clinicaltrials.gov/study/NCT06439836 | https://clinicaltrials.gov/study/NCT06528210 | https://clinicaltrials.gov/study/NCT04681469 | https://clinicaltrials.gov/study/NCT05505825 | https://clinicaltrials.gov/study/NCT07692932 | https://clinicaltrials.gov/study/NCT06576973 | https://clinicaltrials.gov/study/NCT05440864 | https://clinicaltrials.gov/study/NCT03827044 | https://clinicaltrials.gov/study/NCT04512534 | https://clinicaltrials.gov/study/NCT03601455 | https://clinicaltrials.gov/study/NCT05320640 | https://clinicaltrials.gov/study/NCT06151743 | https://clinicaltrials.gov/study/NCT04019964 | https://clinicaltrials.gov/study/NCT03544723 | https://clinicaltrials.gov/study/NCT03697304 | https://clinicaltrials.gov/study/NCT03816345 | https://clinicaltrials.gov/study/NCT03694834 | https://clinicaltrials.gov/study/NCT06020651 | https://clinicaltrials.gov/study/NCT07645742 | https://clinicaltrials.gov/study/NCT03454243 | https://clinicaltrials.gov/study/NCT05860335 | https://clinicaltrials.gov/study/NCT07319429 | https://clinicaltrials.gov/study/NCT03607890 | https://clinicaltrials.gov/study/NCT04389151 | https://clinicaltrials.gov/study/NCT04095273 | https://clinicaltrials.gov/study/NCT07270666 | https://clinicaltrials.gov/study/NCT07243626 | https://clinicaltrials.gov/study/NCT05879822 | https://clinicaltrials.gov/study/NCT05550558 | https://clinicaltrials.gov/study/NCT06914297 | https://clinicaltrials.gov/study/NCT03026140 | https://clinicaltrials.gov/study/NCT04104893 | https://clinicaltrials.gov/study/NCT07690540 | https://clinicaltrials.gov/study/NCT06549855 | https://clinicaltrials.gov/study/NCT06270706 | https://clinicaltrials.gov/study/NCT03983759 | https://clinicaltrials.gov/study/NCT04150900 | https://clinicaltrials.gov/study/NCT04576091 | https://clinicaltrials.gov/study/NCT02360345 | https://clinicaltrials.gov/study/NCT06360575