Manual Review Required

MET exon 14 skipping

solid tumor basket · Combination Therapy

MET exon 14 skipping is flagged as manual review required because public trials show inclusion required evidence in 168 contexts. FDA CDx context should be reviewed manually. Threshold text varies across public records.

Role evidence

Usage summary

Strongest role: Inclusion Required

Inclusion-required count: 144

Treatment-assignment count: 1

Stratification count: 1

Threshold snippets

Fragmentation view

Threshold count: 37

Common snippets: BRAF V600E | BRAF V600E | KRAS G12C

Threshold label: Fragmented

FDA CDx context

Mapping summary

CDx label: Fda Cdx Context Not Found

CDx maturity score: 1/5

Confidence: Low

Patent-density signal

Diagnostic appendix

Signal count: 0

Recent signals: 0

Density label: Low

Source links

Evidence paths

https://clinicaltrials.gov/study/NCT02228681 | https://clinicaltrials.gov/study/NCT07334301 | https://clinicaltrials.gov/study/NCT03513952 | https://clinicaltrials.gov/study/NCT07226349 | https://clinicaltrials.gov/study/NCT00357318 | https://clinicaltrials.gov/study/NCT00055913 | https://clinicaltrials.gov/study/NCT00287937 | https://clinicaltrials.gov/study/NCT03442556 | https://clinicaltrials.gov/study/NCT07683013 | https://clinicaltrials.gov/study/NCT00918385 | https://clinicaltrials.gov/study/NCT00354185 | https://clinicaltrials.gov/study/NCT00415324 | https://clinicaltrials.gov/study/NCT01208454 | https://clinicaltrials.gov/study/NCT00060112 | https://clinicaltrials.gov/study/NCT01193595 | https://clinicaltrials.gov/study/NCT00084877 | https://clinicaltrials.gov/study/NCT01154426 | https://clinicaltrials.gov/study/NCT01188499 | https://clinicaltrials.gov/study/NCT00714181 | https://clinicaltrials.gov/study/NCT00415194 | https://clinicaltrials.gov/study/NCT00413686 | https://clinicaltrials.gov/study/NCT03254927 | https://clinicaltrials.gov/study/NCT00041106 | https://clinicaltrials.gov/study/NCT00387127 | https://clinicaltrials.gov/study/NCT07179783 | https://clinicaltrials.gov/study/NCT02923466 | https://clinicaltrials.gov/study/NCT02319018 | https://clinicaltrials.gov/study/NCT02952586 | https://clinicaltrials.gov/study/NCT02795429 | https://clinicaltrials.gov/study/NCT02567422 | https://clinicaltrials.gov/study/NCT00390676 | https://clinicaltrials.gov/study/NCT01141244 | https://clinicaltrials.gov/study/NCT03431350 | https://clinicaltrials.gov/study/NCT03742895 | https://clinicaltrials.gov/study/NCT01511536 | https://clinicaltrials.gov/study/NCT00112593 | https://clinicaltrials.gov/study/NCT01654965 | https://clinicaltrials.gov/study/NCT02554812 | https://clinicaltrials.gov/study/NCT05240898 | https://clinicaltrials.gov/study/NCT02975882 | https://clinicaltrials.gov/study/NCT01289522 | https://clinicaltrials.gov/study/NCT04912466 | https://clinicaltrials.gov/study/NCT01282463 | https://clinicaltrials.gov/study/NCT00725634 | https://clinicaltrials.gov/study/NCT00047047 | https://clinicaltrials.gov/study/NCT03814005 | https://clinicaltrials.gov/study/NCT01688973 | https://clinicaltrials.gov/study/NCT00906373 | https://clinicaltrials.gov/study/NCT01325441 | https://clinicaltrials.gov/study/NCT00861419 | https://clinicaltrials.gov/study/NCT06600789 | https://clinicaltrials.gov/study/NCT00087217 | https://clinicaltrials.gov/study/NCT01296568 | https://clinicaltrials.gov/study/NCT00678769 | https://clinicaltrials.gov/study/NCT02291055 | https://clinicaltrials.gov/study/NCT00551889 | https://clinicaltrials.gov/study/NCT05824481 | https://clinicaltrials.gov/study/NCT00423865 | https://clinicaltrials.gov/study/NCT00372736 | https://clinicaltrials.gov/study/NCT02392637 | https://clinicaltrials.gov/study/NCT00033449 | https://clinicaltrials.gov/study/NCT04988074 | https://clinicaltrials.gov/study/NCT00255658 | https://clinicaltrials.gov/study/NCT00137436 | https://clinicaltrials.gov/study/NCT02279719 | https://clinicaltrials.gov/study/NCT02466971 | https://clinicaltrials.gov/study/NCT03377556 | https://clinicaltrials.gov/study/NCT01625156 | https://clinicaltrials.gov/study/NCT01130519 | https://clinicaltrials.gov/study/NCT07351903 | https://clinicaltrials.gov/study/NCT00042874 | https://clinicaltrials.gov/study/NCT00734890 | https://clinicaltrials.gov/study/NCT02145559 | https://clinicaltrials.gov/study/NCT00648648 | https://clinicaltrials.gov/study/NCT04800822 | https://clinicaltrials.gov/study/NCT00126620 | https://clinicaltrials.gov/study/NCT04604132 | https://clinicaltrials.gov/study/NCT02929693 | https://clinicaltrials.gov/study/NCT05132413 | https://clinicaltrials.gov/study/NCT01947023 | https://clinicaltrials.gov/study/NCT02689336 | https://clinicaltrials.gov/study/NCT00728390 | https://clinicaltrials.gov/study/NCT06483672 | https://clinicaltrials.gov/study/NCT01154140 | https://clinicaltrials.gov/study/NCT06166836 | https://clinicaltrials.gov/study/NCT06983743 | https://clinicaltrials.gov/study/NCT07615413 | https://clinicaltrials.gov/study/NCT07209111 | https://clinicaltrials.gov/study/NCT07608224 | https://clinicaltrials.gov/study/NCT06376136 | https://clinicaltrials.gov/study/NCT05495724 | https://clinicaltrials.gov/study/NCT05618925 | https://clinicaltrials.gov/study/NCT03723967 | https://clinicaltrials.gov/study/NCT06869473 | https://clinicaltrials.gov/study/NCT07243951 | https://clinicaltrials.gov/study/NCT03298451 | https://clinicaltrials.gov/study/NCT04989218 | https://clinicaltrials.gov/study/NCT03324282 | https://clinicaltrials.gov/study/NCT02325739 | https://clinicaltrials.gov/study/NCT04803994 | https://clinicaltrials.gov/study/NCT05998941 | https://clinicaltrials.gov/study/NCT02592551 | https://clinicaltrials.gov/study/NCT04698213 | https://clinicaltrials.gov/study/NCT07647289 | https://clinicaltrials.gov/study/NCT02608268 | https://clinicaltrials.gov/study/NCT07027436 | https://clinicaltrials.gov/study/NCT07177716 | https://clinicaltrials.gov/study/NCT07316361 | https://clinicaltrials.gov/study/NCT04833257 | https://clinicaltrials.gov/study/NCT03568097 | https://clinicaltrials.gov/study/NCT07079410 | https://clinicaltrials.gov/study/NCT03556839 | https://clinicaltrials.gov/study/NCT04063163 | https://clinicaltrials.gov/study/NCT05608395 | https://clinicaltrials.gov/study/NCT03267940 | https://clinicaltrials.gov/study/NCT02304393 | https://clinicaltrials.gov/study/NCT04548271 | https://clinicaltrials.gov/study/NCT04237649 | https://clinicaltrials.gov/study/NCT05919030 | https://clinicaltrials.gov/study/NCT07251062 | https://clinicaltrials.gov/study/NCT04882462 | https://clinicaltrials.gov/study/NCT03693573 | https://clinicaltrials.gov/study/NCT06886347 | https://clinicaltrials.gov/study/NCT05151549 | https://clinicaltrials.gov/study/NCT02882308 | https://clinicaltrials.gov/study/NCT06334991 | https://clinicaltrials.gov/study/NCT02549651 | https://clinicaltrials.gov/study/NCT04447716 | https://clinicaltrials.gov/study/NCT04813107 | https://clinicaltrials.gov/study/NCT04052204 | https://clinicaltrials.gov/study/NCT07622225 | https://clinicaltrials.gov/study/NCT05241132 | https://clinicaltrials.gov/study/NCT07554768 | https://clinicaltrials.gov/study/NCT06393816 | https://clinicaltrials.gov/study/NCT04459078 | https://clinicaltrials.gov/study/NCT06532539 | https://clinicaltrials.gov/study/NCT02635672 | https://clinicaltrials.gov/study/NCT02912572 | https://clinicaltrials.gov/study/NCT07403721 | https://clinicaltrials.gov/study/NCT04458259 | https://clinicaltrials.gov/study/NCT07108270 | https://clinicaltrials.gov/study/NCT06771154 | https://clinicaltrials.gov/study/NCT06873854 | https://clinicaltrials.gov/study/NCT05005728 | https://clinicaltrials.gov/study/NCT06331598 | https://clinicaltrials.gov/study/NCT06035133 | https://clinicaltrials.gov/study/NCT05729646 | https://clinicaltrials.gov/study/NCT06341114 | https://clinicaltrials.gov/study/NCT04576104 | https://clinicaltrials.gov/study/NCT05272709 | https://clinicaltrials.gov/study/NCT06279130 | https://clinicaltrials.gov/study/NCT06417736 | https://clinicaltrials.gov/study/NCT02912559 | https://clinicaltrials.gov/study/NCT03911557 | https://clinicaltrials.gov/study/NCT03144687 | https://clinicaltrials.gov/study/NCT05464433 | https://clinicaltrials.gov/study/NCT03151408 | https://clinicaltrials.gov/study/NCT03565991 | https://clinicaltrials.gov/study/NCT03617913 | https://clinicaltrials.gov/study/NCT04068194 | https://clinicaltrials.gov/study/NCT02320487 | https://clinicaltrials.gov/study/NCT06350006 | https://clinicaltrials.gov/study/NCT06041035 | https://clinicaltrials.gov/study/NCT06446388 | https://clinicaltrials.gov/study/NCT07151872 | https://clinicaltrials.gov/study/NCT03836157 | https://clinicaltrials.gov/study/NCT01688791 | https://clinicaltrials.gov/study/NCT04116541