Manual Review Required

MET exon 14 skipping

NSCLC · Therapy Not Normalized

MET exon 14 skipping is flagged as manual review required because public trials show inclusion required evidence in 183 contexts. FDA CDx context should be reviewed manually. Threshold text varies across public records.

Role evidence

Usage summary

Strongest role: Inclusion Required

Inclusion-required count: 157

Treatment-assignment count: 1

Stratification count: 1

Threshold snippets

Fragmentation view

Threshold count: 51

Common snippets: BRAF V600E | EGFR exon 19 deletion | EGFR exon 19 deletion

Threshold label: Fragmented

FDA CDx context

Mapping summary

CDx label: Fda Cdx Context Not Found

CDx maturity score: 1/5

Confidence: Low

Patent-density signal

Diagnostic appendix

Signal count: 0

Recent signals: 0

Density label: Low

Source links

Evidence paths

https://clinicaltrials.gov/study/NCT00063154 | https://clinicaltrials.gov/study/NCT03662477 | https://clinicaltrials.gov/study/NCT01153984 | https://clinicaltrials.gov/study/NCT00245063 | https://clinicaltrials.gov/study/NCT05089734 | https://clinicaltrials.gov/study/NCT02642042 | https://clinicaltrials.gov/study/NCT00685750 | https://clinicaltrials.gov/study/NCT07291037 | https://clinicaltrials.gov/study/NCT00932893 | https://clinicaltrials.gov/study/NCT02650375 | https://clinicaltrials.gov/study/NCT02916745 | https://clinicaltrials.gov/study/NCT03695757 | https://clinicaltrials.gov/study/NCT06051695 | https://clinicaltrials.gov/study/NCT02568267 | https://clinicaltrials.gov/study/NCT01676714 | https://clinicaltrials.gov/study/NCT06903117 | https://clinicaltrials.gov/study/NCT04795713 | https://clinicaltrials.gov/study/NCT06945523 | https://clinicaltrials.gov/study/NCT00446225 | https://clinicaltrials.gov/study/NCT00556712 | https://clinicaltrials.gov/study/NCT06768151 | https://clinicaltrials.gov/study/NCT02417701 | https://clinicaltrials.gov/study/NCT04250545 | https://clinicaltrials.gov/study/NCT02013206 | https://clinicaltrials.gov/study/NCT02607813 | https://clinicaltrials.gov/study/NCT02811354 | https://clinicaltrials.gov/study/NCT07229339 | https://clinicaltrials.gov/study/NCT06758557 | https://clinicaltrials.gov/study/NCT05653752 | https://clinicaltrials.gov/study/NCT01829217 | https://clinicaltrials.gov/study/NCT03396185 | https://clinicaltrials.gov/study/NCT02404675 | https://clinicaltrials.gov/study/NCT01415011 | https://clinicaltrials.gov/study/NCT02314364 | https://clinicaltrials.gov/study/NCT01378962 | https://clinicaltrials.gov/study/NCT01858389 | https://clinicaltrials.gov/study/NCT01933347 | https://clinicaltrials.gov/study/NCT02744664 | https://clinicaltrials.gov/study/NCT05364073 | https://clinicaltrials.gov/study/NCT04248829 | https://clinicaltrials.gov/study/NCT06864624 | https://clinicaltrials.gov/study/NCT05527808 | https://clinicaltrials.gov/study/NCT01530334 | https://clinicaltrials.gov/study/NCT03720873 | https://clinicaltrials.gov/study/NCT07554846 | https://clinicaltrials.gov/study/NCT00858403 | https://clinicaltrials.gov/study/NCT04075396 | https://clinicaltrials.gov/study/NCT01124864 | https://clinicaltrials.gov/study/NCT06382116 | https://clinicaltrials.gov/study/NCT02420405 | https://clinicaltrials.gov/study/NCT05104788 | https://clinicaltrials.gov/study/NCT06329895 | https://clinicaltrials.gov/study/NCT01121393 | https://clinicaltrials.gov/study/NCT02113813 | https://clinicaltrials.gov/study/NCT04576208 | https://clinicaltrials.gov/study/NCT00266877 | https://clinicaltrials.gov/study/NCT04619004 | https://clinicaltrials.gov/study/NCT06253871 | https://clinicaltrials.gov/study/NCT03856697 | https://clinicaltrials.gov/study/NCT03082300 | https://clinicaltrials.gov/study/NCT03452592 | https://clinicaltrials.gov/study/NCT05519293 | https://clinicaltrials.gov/study/NCT00556322 | https://clinicaltrials.gov/study/NCT06590194 | https://clinicaltrials.gov/study/NCT03808662 | https://clinicaltrials.gov/study/NCT07268469 | https://clinicaltrials.gov/study/NCT06641609 | https://clinicaltrials.gov/study/NCT03866499 | https://clinicaltrials.gov/study/NCT01784549 | https://clinicaltrials.gov/study/NCT06563999 | https://clinicaltrials.gov/study/NCT01853826 | https://clinicaltrials.gov/study/NCT05299125 | https://clinicaltrials.gov/study/NCT05555212 | https://clinicaltrials.gov/study/NCT06221670 | https://clinicaltrials.gov/study/NCT05277701 | https://clinicaltrials.gov/study/NCT06041776 | https://clinicaltrials.gov/study/NCT06706076 | https://clinicaltrials.gov/study/NCT02805530 | https://clinicaltrials.gov/study/NCT00548093 | https://clinicaltrials.gov/study/NCT07661173 | https://clinicaltrials.gov/study/NCT03066206 | https://clinicaltrials.gov/study/NCT06685718 | https://clinicaltrials.gov/study/NCT03766490 | https://clinicaltrials.gov/study/NCT05146219 | https://clinicaltrials.gov/study/NCT01579630 | https://clinicaltrials.gov/study/NCT02125240 | https://clinicaltrials.gov/study/NCT02788058 | https://clinicaltrials.gov/study/NCT01674738 | https://clinicaltrials.gov/study/NCT05257967 | https://clinicaltrials.gov/study/NCT06311981 | https://clinicaltrials.gov/study/NCT06010329 | https://clinicaltrials.gov/study/NCT06956001 | https://clinicaltrials.gov/study/NCT02186301 | https://clinicaltrials.gov/study/NCT06221475 | https://clinicaltrials.gov/study/NCT00411047 | https://clinicaltrials.gov/study/NCT01665417 | https://clinicaltrials.gov/study/NCT05967689 | https://clinicaltrials.gov/study/NCT06631989 | https://clinicaltrials.gov/study/NCT04356118 | https://clinicaltrials.gov/study/NCT05168566 | https://clinicaltrials.gov/study/NCT04129502 | https://clinicaltrials.gov/study/NCT02183883 | https://clinicaltrials.gov/study/NCT07348965 | https://clinicaltrials.gov/study/NCT06080776 | https://clinicaltrials.gov/study/NCT01167244 | https://clinicaltrials.gov/study/NCT06315686 | https://clinicaltrials.gov/study/NCT06281964 | https://clinicaltrials.gov/study/NCT03052608 | https://clinicaltrials.gov/study/NCT05950139 | https://clinicaltrials.gov/study/NCT05740943 | https://clinicaltrials.gov/study/NCT05241028 | https://clinicaltrials.gov/study/NCT01639001 | https://clinicaltrials.gov/study/NCT05015010 | https://clinicaltrials.gov/study/NCT03574402 | https://clinicaltrials.gov/study/NCT06081907 | https://clinicaltrials.gov/study/NCT03856411 | https://clinicaltrials.gov/study/NCT05122806 | https://clinicaltrials.gov/study/NCT05361564 | https://clinicaltrials.gov/study/NCT05487391 | https://clinicaltrials.gov/study/NCT07438600 | https://clinicaltrials.gov/study/NCT00932451 | https://clinicaltrials.gov/study/NCT06955325 | https://clinicaltrials.gov/study/NCT07491497 | https://clinicaltrials.gov/study/NCT05718297 | https://clinicaltrials.gov/study/NCT01121588 | https://clinicaltrials.gov/study/NCT02201992 | https://clinicaltrials.gov/study/NCT05186506 | https://clinicaltrials.gov/study/NCT06074588 | https://clinicaltrials.gov/study/NCT07542704 | https://clinicaltrials.gov/study/NCT06416410 | https://clinicaltrials.gov/study/NCT05383898 | https://clinicaltrials.gov/study/NCT06403436 | https://clinicaltrials.gov/study/NCT04302025 | https://clinicaltrials.gov/study/NCT05119933 | https://clinicaltrials.gov/study/NCT06300177 | https://clinicaltrials.gov/study/NCT05009329 | https://clinicaltrials.gov/study/NCT05005234 | https://clinicaltrials.gov/study/NCT04165031 | https://clinicaltrials.gov/study/NCT06008288 | https://clinicaltrials.gov/study/NCT06208124 | https://clinicaltrials.gov/study/NCT07286149 | https://clinicaltrials.gov/study/NCT04006301 | https://clinicaltrials.gov/study/NCT01730118 | https://clinicaltrials.gov/study/NCT05546268 | https://clinicaltrials.gov/study/NCT04818333 | https://clinicaltrials.gov/study/NCT00073008 | https://clinicaltrials.gov/study/NCT02716038 | https://clinicaltrials.gov/study/NCT03447769 | https://clinicaltrials.gov/study/NCT03030131 | https://clinicaltrials.gov/study/NCT03811652 | https://clinicaltrials.gov/study/NCT02869685 | https://clinicaltrials.gov/study/NCT06865339 | https://clinicaltrials.gov/study/NCT05465733 | https://clinicaltrials.gov/study/NCT07534033 | https://clinicaltrials.gov/study/NCT06966583 | https://clinicaltrials.gov/study/NCT07608835 | https://clinicaltrials.gov/study/NCT05445843 | https://clinicaltrials.gov/study/NCT05770102 | https://clinicaltrials.gov/study/NCT03652077 | https://clinicaltrials.gov/study/NCT02983578 | https://clinicaltrials.gov/study/NCT04059887 | https://clinicaltrials.gov/study/NCT04392505 | https://clinicaltrials.gov/study/NCT05397093 | https://clinicaltrials.gov/study/NCT00191308 | https://clinicaltrials.gov/study/NCT06376253 | https://clinicaltrials.gov/study/NCT05989542 | https://clinicaltrials.gov/study/NCT04084717 | https://clinicaltrials.gov/study/NCT02864992 | https://clinicaltrials.gov/study/NCT05110196 | https://clinicaltrials.gov/study/NCT04923945 | https://clinicaltrials.gov/study/NCT04460729 | https://clinicaltrials.gov/study/NCT04427072 | https://clinicaltrials.gov/study/NCT04926831 | https://clinicaltrials.gov/study/NCT04322578 | https://clinicaltrials.gov/study/NCT05567055 | https://clinicaltrials.gov/study/NCT03088930 | https://clinicaltrials.gov/study/NCT03693339 | https://clinicaltrials.gov/study/NCT02897479 | https://clinicaltrials.gov/study/NCT07156604 | https://clinicaltrials.gov/study/NCT04992858 | https://clinicaltrials.gov/study/NCT06054191 | https://clinicaltrials.gov/study/NCT07153770 | https://clinicaltrials.gov/study/NCT02920996