Manual Review Required

MET exon 14 skipping

NSCLC · Combination Therapy

MET exon 14 skipping is flagged as manual review required because public trials show inclusion required evidence in 112 contexts. FDA CDx context should be reviewed manually.

Role evidence

Usage summary

Strongest role: Inclusion Required

Inclusion-required count: 102

Treatment-assignment count: 2

Stratification count: 0

Threshold snippets

Fragmentation view

Threshold count: 29

Common snippets: BRAF V600E | EGFR exon 19 deletion | EGFR L858R

Threshold label: Moderate

FDA CDx context

Mapping summary

CDx label: Fda Cdx Context Not Found

CDx maturity score: 1/5

Confidence: Low

Patent-density signal

Diagnostic appendix

Signal count: 0

Recent signals: 0

Density label: Low

Source links

Evidence paths

https://clinicaltrials.gov/study/NCT00550173 | https://clinicaltrials.gov/study/NCT01557959 | https://clinicaltrials.gov/study/NCT03568656 | https://clinicaltrials.gov/study/NCT00031681 | https://clinicaltrials.gov/study/NCT01115803 | https://clinicaltrials.gov/study/NCT07115043 | https://clinicaltrials.gov/study/NCT05241873 | https://clinicaltrials.gov/study/NCT01326767 | https://clinicaltrials.gov/study/NCT02328105 | https://clinicaltrials.gov/study/NCT00107250 | https://clinicaltrials.gov/study/NCT01351415 | https://clinicaltrials.gov/study/NCT02264678 | https://clinicaltrials.gov/study/NCT01249443 | https://clinicaltrials.gov/study/NCT01088906 | https://clinicaltrials.gov/study/NCT00602030 | https://clinicaltrials.gov/study/NCT01798485 | https://clinicaltrials.gov/study/NCT02321501 | https://clinicaltrials.gov/study/NCT05500508 | https://clinicaltrials.gov/study/NCT00531960 | https://clinicaltrials.gov/study/NCT00094835 | https://clinicaltrials.gov/study/NCT06102928 | https://clinicaltrials.gov/study/NCT07314216 | https://clinicaltrials.gov/study/NCT03074864 | https://clinicaltrials.gov/study/NCT06043973 | https://clinicaltrials.gov/study/NCT04500704 | https://clinicaltrials.gov/study/NCT03399669 | https://clinicaltrials.gov/study/NCT05007938 | https://clinicaltrials.gov/study/NCT06816992 | https://clinicaltrials.gov/study/NCT02036359 | https://clinicaltrials.gov/study/NCT01221077 | https://clinicaltrials.gov/study/NCT01864681 | https://clinicaltrials.gov/study/NCT06945705 | https://clinicaltrials.gov/study/NCT00577707 | https://clinicaltrials.gov/study/NCT07014202 | https://clinicaltrials.gov/study/NCT01719536 | https://clinicaltrials.gov/study/NCT06348927 | https://clinicaltrials.gov/study/NCT06668103 | https://clinicaltrials.gov/study/NCT03775486 | https://clinicaltrials.gov/study/NCT01714908 | https://clinicaltrials.gov/study/NCT00983047 | https://clinicaltrials.gov/study/NCT06971406 | https://clinicaltrials.gov/study/NCT02633189 | https://clinicaltrials.gov/study/NCT07551414 | https://clinicaltrials.gov/study/NCT01859026 | https://clinicaltrials.gov/study/NCT06182761 | https://clinicaltrials.gov/study/NCT02795884 | https://clinicaltrials.gov/study/NCT05223595 | https://clinicaltrials.gov/study/NCT02098954 | https://clinicaltrials.gov/study/NCT02318368 | https://clinicaltrials.gov/study/NCT05800223 | https://clinicaltrials.gov/study/NCT01897480 | https://clinicaltrials.gov/study/NCT03178552 | https://clinicaltrials.gov/study/NCT06334757 | https://clinicaltrials.gov/study/NCT02103257 | https://clinicaltrials.gov/study/NCT06599502 | https://clinicaltrials.gov/study/NCT04552613 | https://clinicaltrials.gov/study/NCT04500717 | https://clinicaltrials.gov/study/NCT02407366 | https://clinicaltrials.gov/study/NCT05973773 | https://clinicaltrials.gov/study/NCT05334277 | https://clinicaltrials.gov/study/NCT02338011 | https://clinicaltrials.gov/study/NCT05358249 | https://clinicaltrials.gov/study/NCT06343064 | https://clinicaltrials.gov/study/NCT05394233 | https://clinicaltrials.gov/study/NCT01580735 | https://clinicaltrials.gov/study/NCT00265317 | https://clinicaltrials.gov/study/NCT00965731 | https://clinicaltrials.gov/study/NCT07354061 | https://clinicaltrials.gov/study/NCT05200481 | https://clinicaltrials.gov/study/NCT04459663 | https://clinicaltrials.gov/study/NCT06746870 | https://clinicaltrials.gov/study/NCT04042558 | https://clinicaltrials.gov/study/NCT06196814 | https://clinicaltrials.gov/study/NCT03164616 | https://clinicaltrials.gov/study/NCT07198841 | https://clinicaltrials.gov/study/NCT07227025 | https://clinicaltrials.gov/study/NCT06594874 | https://clinicaltrials.gov/study/NCT06128551 | https://clinicaltrials.gov/study/NCT05288205 | https://clinicaltrials.gov/study/NCT06963502 | https://clinicaltrials.gov/study/NCT05492045 | https://clinicaltrials.gov/study/NCT04449874 | https://clinicaltrials.gov/study/NCT07468071 | https://clinicaltrials.gov/study/NCT06970132 | https://clinicaltrials.gov/study/NCT06749860 | https://clinicaltrials.gov/study/NCT04940637 | https://clinicaltrials.gov/study/NCT05346952 | https://clinicaltrials.gov/study/NCT03317496 | https://clinicaltrials.gov/study/NCT06974734 | https://clinicaltrials.gov/study/NCT05568212 | https://clinicaltrials.gov/study/NCT05635708 | https://clinicaltrials.gov/study/NCT04776447 | https://clinicaltrials.gov/study/NCT03896074 | https://clinicaltrials.gov/study/NCT04832854 | https://clinicaltrials.gov/study/NCT04167774 | https://clinicaltrials.gov/study/NCT03170960 | https://clinicaltrials.gov/study/NCT05746481 | https://clinicaltrials.gov/study/NCT02888743 | https://clinicaltrials.gov/study/NCT04866017 | https://clinicaltrials.gov/study/NCT04105270 | https://clinicaltrials.gov/study/NCT06982924 | https://clinicaltrials.gov/study/NCT05651022 | https://clinicaltrials.gov/study/NCT03475953 | https://clinicaltrials.gov/study/NCT03472560 | https://clinicaltrials.gov/study/NCT03836066 | https://clinicaltrials.gov/study/NCT00530621 | https://clinicaltrials.gov/study/NCT00762034 | https://clinicaltrials.gov/study/NCT01577654 | https://clinicaltrials.gov/study/NCT05488314 | https://clinicaltrials.gov/study/NCT05800340 | https://clinicaltrials.gov/study/NCT03386929 | https://clinicaltrials.gov/study/NCT04323436