Manual Review Required

EGFR mutation

NSCLC · Therapy Not Normalized

EGFR mutation is flagged as manual review required because public trials show inclusion required evidence in 122 contexts. FDA CDx context exists. Threshold text varies across public records.

Role evidence

Usage summary

Strongest role: Inclusion Required

Inclusion-required count: 87

Treatment-assignment count: 0

Stratification count: 3

Threshold snippets

Fragmentation view

Threshold count: 26

Common snippets: BRAF V600E | EGFR exon 19 deletion | EGFR exon 19 deletion

Threshold label: Fragmented

FDA CDx context

Mapping summary

CDx label: Fda Cdx Context Exists

CDx maturity score: 5/5

Confidence: Low

Patent-density signal

Diagnostic appendix

Signal count: 0

Recent signals: 0

Density label: Low

Source links

Evidence paths

https://clinicaltrials.gov/study/NCT03662477 | https://clinicaltrials.gov/study/NCT01153984 | https://clinicaltrials.gov/study/NCT05089734 | https://clinicaltrials.gov/study/NCT07291037 | https://clinicaltrials.gov/study/NCT02650375 | https://clinicaltrials.gov/study/NCT00446225 | https://clinicaltrials.gov/study/NCT00556712 | https://clinicaltrials.gov/study/NCT04250545 | https://clinicaltrials.gov/study/NCT02013206 | https://clinicaltrials.gov/study/NCT02811354 | https://clinicaltrials.gov/study/NCT07229339 | https://clinicaltrials.gov/study/NCT06758557 | https://clinicaltrials.gov/study/NCT05653752 | https://clinicaltrials.gov/study/NCT01829217 | https://clinicaltrials.gov/study/NCT03396185 | https://clinicaltrials.gov/study/NCT02404675 | https://clinicaltrials.gov/study/NCT01415011 | https://clinicaltrials.gov/study/NCT02314364 | https://clinicaltrials.gov/study/NCT01378962 | https://clinicaltrials.gov/study/NCT01858389 | https://clinicaltrials.gov/study/NCT00986284 | https://clinicaltrials.gov/study/NCT02965885 | https://clinicaltrials.gov/study/NCT01933347 | https://clinicaltrials.gov/study/NCT02744664 | https://clinicaltrials.gov/study/NCT05364073 | https://clinicaltrials.gov/study/NCT04248829 | https://clinicaltrials.gov/study/NCT02961270 | https://clinicaltrials.gov/study/NCT06864624 | https://clinicaltrials.gov/study/NCT05527808 | https://clinicaltrials.gov/study/NCT01530334 | https://clinicaltrials.gov/study/NCT03720873 | https://clinicaltrials.gov/study/NCT07554846 | https://clinicaltrials.gov/study/NCT00858403 | https://clinicaltrials.gov/study/NCT04075396 | https://clinicaltrials.gov/study/NCT01124864 | https://clinicaltrials.gov/study/NCT06382116 | https://clinicaltrials.gov/study/NCT02420405 | https://clinicaltrials.gov/study/NCT05104788 | https://clinicaltrials.gov/study/NCT06329895 | https://clinicaltrials.gov/study/NCT01121393 | https://clinicaltrials.gov/study/NCT02113813 | https://clinicaltrials.gov/study/NCT04576208 | https://clinicaltrials.gov/study/NCT00266877 | https://clinicaltrials.gov/study/NCT04619004 | https://clinicaltrials.gov/study/NCT03856697 | https://clinicaltrials.gov/study/NCT03082300 | https://clinicaltrials.gov/study/NCT03452592 | https://clinicaltrials.gov/study/NCT05519293 | https://clinicaltrials.gov/study/NCT00556322 | https://clinicaltrials.gov/study/NCT06590194 | https://clinicaltrials.gov/study/NCT03808662 | https://clinicaltrials.gov/study/NCT07268469 | https://clinicaltrials.gov/study/NCT06641609 | https://clinicaltrials.gov/study/NCT03866499 | https://clinicaltrials.gov/study/NCT01784549 | https://clinicaltrials.gov/study/NCT06563999 | https://clinicaltrials.gov/study/NCT01853826 | https://clinicaltrials.gov/study/NCT05299125 | https://clinicaltrials.gov/study/NCT05555212 | https://clinicaltrials.gov/study/NCT06221670 | https://clinicaltrials.gov/study/NCT05277701 | https://clinicaltrials.gov/study/NCT06041776 | https://clinicaltrials.gov/study/NCT06706076 | https://clinicaltrials.gov/study/NCT06987734 | https://clinicaltrials.gov/study/NCT00548093 | https://clinicaltrials.gov/study/NCT07661173 | https://clinicaltrials.gov/study/NCT03066206 | https://clinicaltrials.gov/study/NCT06685718 | https://clinicaltrials.gov/study/NCT03766490 | https://clinicaltrials.gov/study/NCT05146219 | https://clinicaltrials.gov/study/NCT01579630 | https://clinicaltrials.gov/study/NCT00567359 | https://clinicaltrials.gov/study/NCT02125240 | https://clinicaltrials.gov/study/NCT02788058 | https://clinicaltrials.gov/study/NCT01674738 | https://clinicaltrials.gov/study/NCT05257967 | https://clinicaltrials.gov/study/NCT06311981 | https://clinicaltrials.gov/study/NCT06010329 | https://clinicaltrials.gov/study/NCT06956001 | https://clinicaltrials.gov/study/NCT02186301 | https://clinicaltrials.gov/study/NCT06221475 | https://clinicaltrials.gov/study/NCT00411047 | https://clinicaltrials.gov/study/NCT01665417 | https://clinicaltrials.gov/study/NCT05967689 | https://clinicaltrials.gov/study/NCT06631989 | https://clinicaltrials.gov/study/NCT05168566 | https://clinicaltrials.gov/study/NCT04129502 | https://clinicaltrials.gov/study/NCT02183883 | https://clinicaltrials.gov/study/NCT07348965 | https://clinicaltrials.gov/study/NCT06080776 | https://clinicaltrials.gov/study/NCT01167244 | https://clinicaltrials.gov/study/NCT06315686 | https://clinicaltrials.gov/study/NCT06281964 | https://clinicaltrials.gov/study/NCT06081907 | https://clinicaltrials.gov/study/NCT03856411 | https://clinicaltrials.gov/study/NCT05361564 | https://clinicaltrials.gov/study/NCT05487391 | https://clinicaltrials.gov/study/NCT07438600 | https://clinicaltrials.gov/study/NCT00932451 | https://clinicaltrials.gov/study/NCT06955325 | https://clinicaltrials.gov/study/NCT06074588 | https://clinicaltrials.gov/study/NCT06403436 | https://clinicaltrials.gov/study/NCT02869685 | https://clinicaltrials.gov/study/NCT06865339 | https://clinicaltrials.gov/study/NCT05465733 | https://clinicaltrials.gov/study/NCT06966583 | https://clinicaltrials.gov/study/NCT05445843 | https://clinicaltrials.gov/study/NCT04059887 | https://clinicaltrials.gov/study/NCT05397093 | https://clinicaltrials.gov/study/NCT00191308 | https://clinicaltrials.gov/study/NCT05989542 | https://clinicaltrials.gov/study/NCT02864992 | https://clinicaltrials.gov/study/NCT05110196 | https://clinicaltrials.gov/study/NCT04923945 | https://clinicaltrials.gov/study/NCT04460729 | https://clinicaltrials.gov/study/NCT04427072 | https://clinicaltrials.gov/study/NCT04322578 | https://clinicaltrials.gov/study/NCT05567055 | https://clinicaltrials.gov/study/NCT02897479 | https://clinicaltrials.gov/study/NCT04992858 | https://clinicaltrials.gov/study/NCT07153770 | https://clinicaltrials.gov/study/NCT02920996