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TreelipBiomarker Patient-Selection Radar
Solid Tumor OncologyMethodology
Manual Review Required

EGFR L858R

solid tumor basket · Small Molecule Inhibitor

EGFR L858R is flagged as manual review required because public trials show inclusion required evidence in 34 contexts. FDA CDx context should be reviewed manually.

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Role evidence

Usage summary

Strongest role: Inclusion Required

Inclusion-required count: 19

Treatment-assignment count: 1

Stratification count: 0

Threshold snippets

Fragmentation view

Threshold count: 15

Common snippets: PD-L1 CPS ≥1 | BRAF V600E | BRAF V600E

Threshold label: Moderate

FDA CDx context

Mapping summary

CDx label: Fda Cdx Context Not Found

CDx maturity score: 1/5

Confidence: Low

Patent-density signal

Diagnostic appendix

Signal count: 0

Recent signals: 0

Density label: Low

Source links

Evidence paths

https://clinicaltrials.gov/study/NCT04072042 | https://clinicaltrials.gov/study/NCT01332279 | https://clinicaltrials.gov/study/NCT03065387 | https://clinicaltrials.gov/study/NCT02219711 | https://clinicaltrials.gov/study/NCT07662720 | https://clinicaltrials.gov/study/NCT03786237 | https://clinicaltrials.gov/study/NCT04954001 | https://clinicaltrials.gov/study/NCT03175497 | https://clinicaltrials.gov/study/NCT01582191 | https://clinicaltrials.gov/study/NCT01999972 | https://clinicaltrials.gov/study/NCT02746081 | https://clinicaltrials.gov/study/NCT01692496 | https://clinicaltrials.gov/study/NCT02432417 | https://clinicaltrials.gov/study/NCT05710406 | https://clinicaltrials.gov/study/NCT05370469 | https://clinicaltrials.gov/study/NCT04591002 | https://clinicaltrials.gov/study/NCT01573702 | https://clinicaltrials.gov/study/NCT05578092 | https://clinicaltrials.gov/study/NCT06322095 | https://clinicaltrials.gov/study/NCT01449201 | https://clinicaltrials.gov/study/NCT04222335 | https://clinicaltrials.gov/study/NCT05638295 | https://clinicaltrials.gov/study/NCT03994796 | https://clinicaltrials.gov/study/NCT04185883 | https://clinicaltrials.gov/study/NCT06804824 | https://clinicaltrials.gov/study/NCT02268747 | https://clinicaltrials.gov/study/NCT00551850 | https://clinicaltrials.gov/study/NCT03082534 | https://clinicaltrials.gov/study/NCT06418724 | https://clinicaltrials.gov/study/NCT07497919 | https://clinicaltrials.gov/study/NCT03454243 | https://clinicaltrials.gov/study/NCT05860335 | https://clinicaltrials.gov/study/NCT04095273 | https://clinicaltrials.gov/study/NCT04104893