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TreelipBiomarker Patient-Selection Radar
Solid Tumor OncologyMethodology
Manual Review Required

EGFR L858R

solid tumor basket · Combination Therapy

EGFR L858R is flagged as manual review required because public trials show inclusion required evidence in 31 contexts. FDA CDx context should be reviewed manually.

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Role evidence

Usage summary

Strongest role: Inclusion Required

Inclusion-required count: 16

Treatment-assignment count: 0

Stratification count: 0

Threshold snippets

Fragmentation view

Threshold count: 6

Common snippets: BRAF V600E | BRAF V600E | PD-L1 CPS≥1

Threshold label: Moderate

FDA CDx context

Mapping summary

CDx label: Fda Cdx Context Not Found

CDx maturity score: 1/5

Confidence: Low

Patent-density signal

Diagnostic appendix

Signal count: 0

Recent signals: 0

Density label: Low

Source links

Evidence paths

https://clinicaltrials.gov/study/NCT00055913 | https://clinicaltrials.gov/study/NCT07683013 | https://clinicaltrials.gov/study/NCT03254927 | https://clinicaltrials.gov/study/NCT00041106 | https://clinicaltrials.gov/study/NCT02554812 | https://clinicaltrials.gov/study/NCT01289522 | https://clinicaltrials.gov/study/NCT01282463 | https://clinicaltrials.gov/study/NCT03814005 | https://clinicaltrials.gov/study/NCT01688973 | https://clinicaltrials.gov/study/NCT01325441 | https://clinicaltrials.gov/study/NCT00678769 | https://clinicaltrials.gov/study/NCT00033449 | https://clinicaltrials.gov/study/NCT00137436 | https://clinicaltrials.gov/study/NCT01130519 | https://clinicaltrials.gov/study/NCT04800822 | https://clinicaltrials.gov/study/NCT00126620 | https://clinicaltrials.gov/study/NCT02929693 | https://clinicaltrials.gov/study/NCT05132413 | https://clinicaltrials.gov/study/NCT01947023 | https://clinicaltrials.gov/study/NCT02689336 | https://clinicaltrials.gov/study/NCT00728390 | https://clinicaltrials.gov/study/NCT06483672 | https://clinicaltrials.gov/study/NCT06869473 | https://clinicaltrials.gov/study/NCT04698213 | https://clinicaltrials.gov/study/NCT07079410 | https://clinicaltrials.gov/study/NCT03556839 | https://clinicaltrials.gov/study/NCT04548271 | https://clinicaltrials.gov/study/NCT07251062 | https://clinicaltrials.gov/study/NCT04882462 | https://clinicaltrials.gov/study/NCT04459078 | https://clinicaltrials.gov/study/NCT04116541