Manual Review Required

EGFR exon 19 deletion

NSCLC · Small Molecule Inhibitor

EGFR exon 19 deletion is flagged as manual review required because public trials show inclusion required evidence in 187 contexts. FDA CDx context should be reviewed manually. Threshold text varies across public records.

Role evidence

Usage summary

Strongest role: Inclusion Required

Inclusion-required count: 167

Treatment-assignment count: 0

Stratification count: 1

Threshold snippets

Fragmentation view

Threshold count: 60

Common snippets: EGFR exon 19 deletion | BRAF V600E | EGFR L858R

Threshold label: Fragmented

FDA CDx context

Mapping summary

CDx label: Fda Cdx Context Not Found

CDx maturity score: 1/5

Confidence: Low

Patent-density signal

Diagnostic appendix

Signal count: 0

Recent signals: 0

Density label: Low

Source links

Evidence paths

https://clinicaltrials.gov/study/NCT01121575 | https://clinicaltrials.gov/study/NCT01259089 | https://clinicaltrials.gov/study/NCT03191149 | https://clinicaltrials.gov/study/NCT03944772 | https://clinicaltrials.gov/study/NCT01608022 | https://clinicaltrials.gov/study/NCT04335292 | https://clinicaltrials.gov/study/NCT02789345 | https://clinicaltrials.gov/study/NCT05144698 | https://clinicaltrials.gov/study/NCT02496663 | https://clinicaltrials.gov/study/NCT04028778 | https://clinicaltrials.gov/study/NCT04612673 | https://clinicaltrials.gov/study/NCT01647711 | https://clinicaltrials.gov/study/NCT00079235 | https://clinicaltrials.gov/study/NCT01904916 | https://clinicaltrials.gov/study/NCT01169675 | https://clinicaltrials.gov/study/NCT06304441 | https://clinicaltrials.gov/study/NCT00874419 | https://clinicaltrials.gov/study/NCT01774526 | https://clinicaltrials.gov/study/NCT04513301 | https://clinicaltrials.gov/study/NCT03586453 | https://clinicaltrials.gov/study/NCT07535437 | https://clinicaltrials.gov/study/NCT05382728 | https://clinicaltrials.gov/study/NCT05489731 | https://clinicaltrials.gov/study/NCT06671379 | https://clinicaltrials.gov/study/NCT04007835 | https://clinicaltrials.gov/study/NCT03823625 | https://clinicaltrials.gov/study/NCT02330367 | https://clinicaltrials.gov/study/NCT04581824 | https://clinicaltrials.gov/study/NCT02197247 | https://clinicaltrials.gov/study/NCT05104281 | https://clinicaltrials.gov/study/NCT04410796 | https://clinicaltrials.gov/study/NCT04908956 | https://clinicaltrials.gov/study/NCT03653546 | https://clinicaltrials.gov/study/NCT01880515 | https://clinicaltrials.gov/study/NCT05263947 | https://clinicaltrials.gov/study/NCT04816838 | https://clinicaltrials.gov/study/NCT07295821 | https://clinicaltrials.gov/study/NCT02025114 | https://clinicaltrials.gov/study/NCT06391944 | https://clinicaltrials.gov/study/NCT04770688 | https://clinicaltrials.gov/study/NCT05261399 | https://clinicaltrials.gov/study/NCT01802632 | https://clinicaltrials.gov/study/NCT01405079 | https://clinicaltrials.gov/study/NCT02803203 | https://clinicaltrials.gov/study/NCT02274337 | https://clinicaltrials.gov/study/NCT05805631 | https://clinicaltrials.gov/study/NCT06185400 | https://clinicaltrials.gov/study/NCT02864251 | https://clinicaltrials.gov/study/NCT07271446 | https://clinicaltrials.gov/study/NCT03778229 | https://clinicaltrials.gov/study/NCT03991403 | https://clinicaltrials.gov/study/NCT06350097 | https://clinicaltrials.gov/study/NCT01337765 | https://clinicaltrials.gov/study/NCT05281406 | https://clinicaltrials.gov/study/NCT04872634 | https://clinicaltrials.gov/study/NCT05751018 | https://clinicaltrials.gov/study/NCT01404260 | https://clinicaltrials.gov/study/NCT04765059 | https://clinicaltrials.gov/study/NCT07414927 | https://clinicaltrials.gov/study/NCT07323641 | https://clinicaltrials.gov/study/NCT05326425 | https://clinicaltrials.gov/study/NCT06296745 | https://clinicaltrials.gov/study/NCT05870319 | https://clinicaltrials.gov/study/NCT06306456 | https://clinicaltrials.gov/study/NCT03452150 | https://clinicaltrials.gov/study/NCT06380348 | https://clinicaltrials.gov/study/NCT02163733 | https://clinicaltrials.gov/study/NCT03153358 | https://clinicaltrials.gov/study/NCT05458726 | https://clinicaltrials.gov/study/NCT01570296 | https://clinicaltrials.gov/study/NCT02906163 | https://clinicaltrials.gov/study/NCT02616393 | https://clinicaltrials.gov/study/NCT03414814 | https://clinicaltrials.gov/study/NCT05215548 | https://clinicaltrials.gov/study/NCT06784791 | https://clinicaltrials.gov/study/NCT02326285 | https://clinicaltrials.gov/study/NCT02297425 | https://clinicaltrials.gov/study/NCT05298176 | https://clinicaltrials.gov/study/NCT05338619 | https://clinicaltrials.gov/study/NCT06417814 | https://clinicaltrials.gov/study/NCT03434418 | https://clinicaltrials.gov/study/NCT05153408 | https://clinicaltrials.gov/study/NCT04545710 | https://clinicaltrials.gov/study/NCT05236946 | https://clinicaltrials.gov/study/NCT01610336 | https://clinicaltrials.gov/study/NCT06323148 | https://clinicaltrials.gov/study/NCT01755923 | https://clinicaltrials.gov/study/NCT03703596 | https://clinicaltrials.gov/study/NCT07329322 | https://clinicaltrials.gov/study/NCT04486833 | https://clinicaltrials.gov/study/NCT04777084 | https://clinicaltrials.gov/study/NCT04184921 | https://clinicaltrials.gov/study/NCT06868485 | https://clinicaltrials.gov/study/NCT04438902 | https://clinicaltrials.gov/study/NCT06385483 | https://clinicaltrials.gov/study/NCT03071705 | https://clinicaltrials.gov/study/NCT03799094 | https://clinicaltrials.gov/study/NCT02908750 | https://clinicaltrials.gov/study/NCT02374645 | https://clinicaltrials.gov/study/NCT02335944 | https://clinicaltrials.gov/study/NCT04517526 | https://clinicaltrials.gov/study/NCT04181060 | https://clinicaltrials.gov/study/NCT03050411 | https://clinicaltrials.gov/study/NCT02886195 | https://clinicaltrials.gov/study/NCT03497767 | https://clinicaltrials.gov/study/NCT04141644 | https://clinicaltrials.gov/study/NCT05388669 | https://clinicaltrials.gov/study/NCT04541407 | https://clinicaltrials.gov/study/NCT01026844 | https://clinicaltrials.gov/study/NCT02040064 | https://clinicaltrials.gov/study/NCT06775743 | https://clinicaltrials.gov/study/NCT03623750 | https://clinicaltrials.gov/study/NCT03046992 | https://clinicaltrials.gov/study/NCT01526928 | https://clinicaltrials.gov/study/NCT02716311 | https://clinicaltrials.gov/study/NCT03983811 | https://clinicaltrials.gov/study/NCT04382300 | https://clinicaltrials.gov/study/NCT04099836 | https://clinicaltrials.gov/study/NCT02031601 | https://clinicaltrials.gov/study/NCT01889212 | https://clinicaltrials.gov/study/NCT03810066 | https://clinicaltrials.gov/study/NCT03175224 | https://clinicaltrials.gov/study/NCT05948813 | https://clinicaltrials.gov/study/NCT03916913 | https://clinicaltrials.gov/study/NCT06071013 | https://clinicaltrials.gov/study/NCT06186076 | https://clinicaltrials.gov/study/NCT02759835 | https://clinicaltrials.gov/study/NCT03091491 | https://clinicaltrials.gov/study/NCT04322890 | https://clinicaltrials.gov/study/NCT07315113 | https://clinicaltrials.gov/study/NCT03543683 | https://clinicaltrials.gov/study/NCT04201756 | https://clinicaltrials.gov/study/NCT04974879 | https://clinicaltrials.gov/study/NCT00977470 | https://clinicaltrials.gov/study/NCT04916236 | https://clinicaltrials.gov/study/NCT06905197 | https://clinicaltrials.gov/study/NCT05693090 | https://clinicaltrials.gov/study/NCT04695925 | https://clinicaltrials.gov/study/NCT05686434 | https://clinicaltrials.gov/study/NCT07452224 | https://clinicaltrials.gov/study/NCT04997382 | https://clinicaltrials.gov/study/NCT05845671 | https://clinicaltrials.gov/study/NCT06984588 | https://clinicaltrials.gov/study/NCT07330596 | https://clinicaltrials.gov/study/NCT05014464 | https://clinicaltrials.gov/study/NCT04880863 | https://clinicaltrials.gov/study/NCT05284539 | https://clinicaltrials.gov/study/NCT02010047 | https://clinicaltrials.gov/study/NCT03399487 | https://clinicaltrials.gov/study/NCT05993455 | https://clinicaltrials.gov/study/NCT05398094 | https://clinicaltrials.gov/study/NCT07288034 | https://clinicaltrials.gov/study/NCT05786924 | https://clinicaltrials.gov/study/NCT03114319 | https://clinicaltrials.gov/study/NCT05374538 | https://clinicaltrials.gov/study/NCT04285671 | https://clinicaltrials.gov/study/NCT03865511 | https://clinicaltrials.gov/study/NCT07274384 | https://clinicaltrials.gov/study/NCT07692048 | https://clinicaltrials.gov/study/NCT04367311 | https://clinicaltrials.gov/study/NCT03228667 | https://clinicaltrials.gov/study/NCT03150875 | https://clinicaltrials.gov/study/NCT05004974 | https://clinicaltrials.gov/study/NCT05860296 | https://clinicaltrials.gov/study/NCT05641493 | https://clinicaltrials.gov/study/NCT03786692 | https://clinicaltrials.gov/study/NCT02879617 | https://clinicaltrials.gov/study/NCT04417465 | https://clinicaltrials.gov/study/NCT03236935 | https://clinicaltrials.gov/study/NCT04401059 | https://clinicaltrials.gov/study/NCT04777994 | https://clinicaltrials.gov/study/NCT07689812 | https://clinicaltrials.gov/study/NCT03156114 | https://clinicaltrials.gov/study/NCT02646748 | https://clinicaltrials.gov/study/NCT04198766 | https://clinicaltrials.gov/study/NCT05435846 | https://clinicaltrials.gov/study/NCT03911193 | https://clinicaltrials.gov/study/NCT03240393 | https://clinicaltrials.gov/study/NCT02750215 | https://clinicaltrials.gov/study/NCT03993873 | https://clinicaltrials.gov/study/NCT06031688 | https://clinicaltrials.gov/study/NCT07285148 | https://clinicaltrials.gov/study/NCT05782361 | https://clinicaltrials.gov/study/NCT02414139 | https://clinicaltrials.gov/study/NCT04270591 | https://clinicaltrials.gov/study/NCT04677595 | https://clinicaltrials.gov/study/NCT04868877